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July 8, 1905


JAMA. 1905;XLV(2):103-105. doi:10.1001/jama.1905.52510020025003

PRINCIPLES OF SERUM THERAPY.  Attention has been directed repeatedly to a large group of organisms the toxic constituents of which are integrally associated with the protoplasm of the microbes; the toxic substances are endotoxins. Certain members of this group, of which the typhoid, paratyphoid, colon and dysentery bacilli and the vibrio of cholera are representatives, cause the development of strong bactericidal serums in the immunized animal. In Chapter XIII it was shown that such serums have no power of neutralizing the endotoxins of the corresponding organisms, hence whatever prophylactic and curative properties they may have would seem to depend on the bactericidal action of the amboceptor-complement complex. As to whether the substances which stimulate phagocytosis, i. e., the opsonic or bacteriotropic substances are of importance in the intra vitam action of bactericidal serums remains to be definitely established.It is common knowledge that bactericidal serums have not been successful curative

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