August 29, 1903


JAMA. 1903;XLI(9):559-560. doi:10.1001/jama.1903.02490280029005

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Few available tissues of the body remain for which some one has not produced, or attempted to produce, a specific cytotoxin by immunization. Théohari and Babès have the latest cytotoxin—a gastrotoxin, produced by injecting the mucous membrane of the cardiac end of the stomach of dogs into goats. A part of their method is unusual, in that they suspended the emulsion of tissue in 1 per cent. salicylic acid solution, instead of the normal salt solution which is ordinarily used. The reason for this is not stated, but probably it was to combat the bacteria which no doubt were present in the mucous membrane. Three to four injections of the emulsions, given at intervals of ten to fifteen days, gave a fairly toxic serum, of which 15 to 60 c.c. were injected into the jugular veins of dogs. By way of control, it was found that 60 c.c. of normal

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