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In the University Medical Magazine for October, 1894, there is a brief note of reference to ortho-chlorophenol, quoting N. Simanoffski, who is reported to have used it for reducing hypertrophies of the mucous membrane overlying the inferior turbinates of the nares. Simanoffski made but a preliminary report, and referred also to para-chloro-phenol. The endorsement of ortho-chloro-phenol was of such a nature that I was induced to make some trials with it, as well also as of para-chloro-phenol. Ortho-chloro-phenol is a heavy limpid liquid of exceedingly irritating and pungent odor. It is rapidly soluble for clinic purposes in glycerin, and from this may be reduced in strength again and made soluble in water. For clinic purposes the para-chloro-phenol, which occurs in amorphous crystals, is best used by fusing to the end of a probe. In my work I have fused the crystals to silver. Para-chloro-phenol is not so satisfactory clinically, and
BERENS C. A FEW REMARKS ON THE CLINIC USE OF ORTHO- AND PARA- CHLORO-PHENOL.. JAMA. 1896;XXVII(14):728–730. doi:10.1001/jama.1896.02430920004001b