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September 12, 1903


JAMA. 1903;XLI(11):660-661. doi:10.1001/jama.1903.02490300016003

Everything about the structure of the corpus luteum suggests that it is of glandular nature. If one is examined at about the time of the implantation of the ovum it is seen to consist of rows of succulent cells radiating out from the center, resembling closely the structure of a liver lobule, not the cortex of the adrenal; that is, it resembles a true secreting gland. If it has an internal secretion such as the other organs it would naturally seem that this secretion must play some part in either menstruation or pregnancy, or more likely both, for it appears and disappears with menstruation, and reaches its highest development during the first months of pregnancy. This last indicates most probably a relation to the first phenomena of pregnancy, such as the implantation and the development of the ovum. This phenomenon of the preparation of the uterus for the reception, implantation

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