March 16, 1912


Author Affiliations


From the service of Dr. F. C. Wood, St. Luke's Hospital, New York.

JAMA. 1912;LVIII(11):777-778. doi:10.1001/jama.1912.04260030175015

The atropin therapy of diabetes mellitus has recently been advocated by Rudisch1 and by Forchheimer.2 Carbohydrate tolerance is, according to Rudisch, greater with atropin than without. The more striking results were obtained with atropin sulphate, though in some instances atropin methyl bromid was substituted.

The following two cases of diabetes mellitus were tested out with atropin sulphate. A constant weighed diet, as detailed in the protocols, was given. When the daily variations in the amount of glucose excreted had been reduced to a minimum, atropin sulphate was administered in increasing doses for a sufficiently long period of time to give the drug a chance to exert any action of which it was capable. With both subjects the experiments were continued until toxic effects were observed. Under these conditions the glycosuria should be diminished if atropin sulphate is capable of increasing the carbohydrate tolerance.

Any drug which modifies the

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