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Article
September 2, 1905

VACCINATION DURING ERUPTIVE STAGE OF SMALLPOX.

JAMA. 1905;XLV(10):723. doi:10.1001/jama.1905.02510100057014
Abstract

In a recent issue of the Lancet,1 Dr. J. Cooke Hibbert claims that vaccination or re-vaccination may be successfully performed during the eruptive stage of smallpox, and cites eleven cases in support of his contention, the vaccination in these cases having been performed on the first, third and thirteenth day. This is by no means an uncommon occurrence, as has been demonstrated frequently at the Chicago Isolation Hospital. Patients vaccinated on the second and third day of the eruption, or up to the eighth day, will, as a rule, have a typical take, but not after this time. In a paper by Dr. Heman Spalding,2 published in The Journal several years ago, reference is made to an experimental vaccination of over one hundred smallpox patients after the eighth day of the eruption. In none of these cases was there a take. The case reported by Hibbert in which

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