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May 25, 1912

THE ATROPHY OF MUSCLE AND BONE RESULTING FROM JOINT-DISEASE, INJURY AND FIXATION

JAMA. 1912;LVIII(21):1576-1579. doi:10.1001/jama.1912.04260050252008
Abstract

The disease, injury or fixation of any of the large joints of the body is attended by certain trophic disturbances in the muscles controlling such joints, and in many instances by similar phenomena in the bones composing the joints. That such atrophy of the soft parts accompanies disease and injury of joints has been recognized for a great many years, being alluded to by John Hunter in 1776, Nelaton in 1837, and from that time on occasionally. As to the theory of the cause, whether the atrophy is due to disuse or to some reflex influence or to certain other causes occasionally mentioned has been a good deal discussed without the acceptance of any definite conclusion.1

I wish to call attention to the clinical phenomena accompanying the atrophy of muscles associated with joint-injury and fixation, and to the symptoms of bone atrophy occurring under similar conditions; to present typical

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