This report includes several cases of myomata where sarcomatous changes have occurred. From the number of cases recorded it is evident that the disease is more frequent than heretofore suspected. The sarcoma usually develops in one of several myomata and may be situated in a subperitoneal interstitial or submucous nodule. Until recently it was supposed to be confined chiefly to submucous myomata.
The gross changes are characteristic, the firm cross-grained myomatous tissue being replaced by a homogeneous yellowish white growth devoid of a fibrous arrangement and closely resembling raw pork. Degenerations in the sarcomatous tissue are frequent.
Histologically these growths arc found to develop from two sources:
1. The connective tissue.
2. The uterine muscle.
Those of connective tissue origin may consist:
(a Of spindle shaped cells.
(b) Of round cells.
In those derived from the muscle a direct transition from the muscle fibers into the sarcomatous ones can be
CULLEN TS. SARCOMATOUS TRANSFORMATION OF MYOMATA.. JAMA. 1903;XLI(17):1013–1015. doi:10.1001/jama.1903.92490360015001c