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This monograph presents a novelty for pharmacology and medical jurisprudence, and undoubtedly will be useful in making accessible scattered facts of great practical importance. During the last few years, especially through the investigations of experimental pharmacologists, we have learned of many instances in which the effect of certain substances on living organisms is entirely characteristic, e.g., the detection of epinephrin by its mydriatic effect on the frog's eye; the acetonitrile test of Reid Hunt for thyroid activity, etc. These, together with longer-known instances of characteristic biologic reactions, have been collected by Fühner, and detailed with sufficient information to permit their use for analytical, experimental or legal purposes. There are some serious omissions, such as the test for epinephrin by strips of uterus, and the cock's comb test for ergot, but these will probably be rectified in subsequent editions. Enough facts and information are collected to make the book extremely valuable
Nachweis und Bestimmung von Giften auf Biologischen Wege.. JAMA. 1912;LVIII(23):1814. doi:10.1001/jama.1912.04260060163041