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The ordinary dose of carbolic acid is usually given as from 1 to 3 drops, and 6 or 7 drops have been reported as producing very unfortunate symptoms, while half a dram is said to be almost inevitably fatal unless met by immediate adequate treatment. Nevertheless, we occasionally hear of what seems to be excessive dosage of this powerful agent. The Baccelli treatment of tetanus is an instance of rather heroic dosing, but the most remarkable usage of the remedy is reported from China in the treatment of plague. In a communication which is editorially noticed in the Journal of Tropical Medicine, October 1, Dr. J. C. Thompson reports treating cases of plague in Hong Kong with carbolic acid and in quantities of 144 gr. daily, divided into bi-hourly doses of 12 grains each. With these enormous doses he said he expected to see evidences of carbolic acid poisoning frequently
PLAGUE TREATMENT BY CARBOLIC ACID.. JAMA. 1903;XLI(18):1095. doi:10.1001/jama.1903.02490370037008