January 24, 1914


JAMA. 1914;LXII(4):282-285. doi:10.1001/jama.1914.02560290032011

Robert Willis1 observed "a peculiar morbid state of the renal secretion characterized, not only by a considerable increase in the quantity of fluid elaborated, but a great increase in the quantity of urea it holds dissolved, in some cases to be permanent and habitual." To quote him further, "This is another of the morbid states that has been described under the name of diabetes or diabetes insipidus. I believe it to be the common precursor or recent inquiries have shown it to be the general attendant of mellitic diabetes, as well as the state into which that formidable disease passes under the influence of treatment of a certain kind." Although the preceding was advanced in 1838, practically nothing is known of the condition in America. The library of the New York Academy of Medicine does not contain mention of it in a work of any kind or even a

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