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January 24, 1914

THE LIBERATION OF FORMALDEHYD FROM HEXAMETHYLENAMIN IN PATHOLOGIC FLUIDS

Author Affiliations

CLEVELAND

From the Pharmacological Laboratory, Western Reserve University Medical Department.

JAMA. 1914;LXII(4):295-296. doi:10.1001/jama.1914.02560290045018
Abstract

In a previous publication1 it was shown that the decomposition of hexamethylenamin in the living normal organism takes place only in acid urine and gastric juice, that it depends on the excess hydrogen ion [H+] concentration2 of the fluid, and that in those body fluids which are neutral or truly alkaline (possessing [H+] concentrations of 7.0 or less), no liberation of formaldehyd from hexamethylenamin takes place. It is conceivable, however, that the reactions of certain pathologic fluids may be truly acid. This might be true of those fluids which exhibit pronounced degrees of stasis, putrefaction or those of clinical "acidoses." With this in view, we have investigated the distribution of hexamethylenamin and free formaldehyd, and the reaction of these fluids, according to the methods described in our previous paper.

Through the courtesy of the various staffs of the Lakeside, City and Charity hospitals of Cleveland, the following pathologic

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