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Article
October 21, 1905

THE MORBID ANATOMY OF ASTHENIO BULBAR PARALYSIS.

JAMA. 1905;XLV(17):1250-1251. doi:10.1001/jama.1905.02510170042004
Abstract

Under the designation of asthenic bulbar paralysis or myasthenia gravis pseudoparalytica has been described a condition characterized by weakness and undue readiness of fatigue in certain voluntary muscles, particularly those controlled by the bulbar nerves. The electric irritability of the affected muscles also is quickly exhausted. Sensibility, nutrition and reflex activity remain unaffected. In fatal cases, variable and inconstant changes have been found in the central and peripheral nervous systems and in the absence of definite knowledge the disorder has been considered of toxic origin. More recently, however, hyperplastic and neoplastic alterations have been described in the thymus gland in conjunction with deposits of lymphoid cells in the skeletal muscles.

At a recent meeting of the Pathological Society of London, Dr. E. Farquhar Buzzard1 reported the results of postmortem examination in five cases of asthenic bulbar palsy, with a demonstration of specimens illustrative of the morbid anatomy. In three

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