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Article
February 21, 1914

THE MODIFICATION OF SECONDARY SEXUAL CHARACTERS

JAMA. 1914;LXII(8):618-619. doi:10.1001/jama.1914.02560330036019
Abstract

The belief that the so-called secondary sexual characters are in large measure dependent for their appearance on an influence exerted by the genital glands on the other parts of the reproductive apparatus and on the body generally is not a new one. Castration carried out before the time of puberty prevents the development of these secondary sexual characters, which occurs at this epoch in both sexes. Castration after puberty, though not causing any pronounced changes in the skeleton which has already assumed a permanent form, brings about retrogressive manifestations in the remaining genital organs analogous to those occurring in the female at the climacteric. There was a time, not long since, when these interrelations were supposed to be controlled by nervous connections between the genital glands and the rest of the body. To-day there is a rapidly growing conviction that the secondary sexual characters must be ascribed to the influence

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