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New York, Nov. 21, 1903.
To the Editor:
—In my communication, "Dose of Carbolic Acid and Dosage in General," which appeared in The Journal, November 21, I said that our so-called science of posology is in an uncertain, chaotic condition. There are many intrinsic reasons for this chaos and uncertainty, but I wish to call attention to one cause, which contributes toward that chaos, sows confusion in the physician's mind and not infrequently throws him off the track. Two or three days ago the question of dosage came up. A medical friend, a recent graduate, said that the dose of belladonna as given in the books is entirely too small. He has a child under treatment suffering with pertussis; he has been trying to put it under the influence of belladonna. He started with one-drop doses of the fluid extract, but as they had no effect, he began gradually to
Robinson WJ. One of the Causes of the Chaos in Posology.. JAMA. 1903;XLI(22):1356-1357. doi:10.1001/jama.1903.02490410046012