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February 21, 1914


JAMA. 1914;LXII(8):620. doi:10.1001/jama.1914.02560330038021

Inasmuch as the newer researches concerning the intake and output of cholesterol in the body give little evidence of any new formation of this important compound in the organism of the higher animals, information regarding the ways in which the supply of this lipoid is altered must be heartily welcomed. Cholesterol has long attracted attention because it occurs pathologically not only in the familiar form of gall-stones, but also in tissues the cells of which are undergoing slow destruction and in which absorption appears to be poor. It is also frequently found in atheromatous patches in the blood-vessels, encapsulated caseous areas, old infarcts and hematomas, inspissated pus collections, dermoid cysts, hydrocele fluids, etc.; and in the cholesteatomatous tumors of the ear and cranial cavity. But such occurrences of cholesterol are, perhaps, of secondary moment in comparison with the rôle which it plays in the behavior of the blood-corpuscles and the

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