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March 7, 1914


JAMA. 1914;LXII(10):778-779. doi:10.1001/jama.1914.02560350038017

The discovery of the blood-pressure-raising potency of extracts of the suprarenal glands and the final isolation of epinephrin as the active substance involved therein has served for some time to direct attention anew to the possible function of the organs which produce it. For half a century before this the correlation of the suprarenals with Addison's disease and the experimental demonstration of their indispensability for life made by Brown-Séquard and others, had awakened some interest in the question as to how these glands serve the organism. But the study of their real physiologic significance unquestionably received a new impetus from the classic investigations of Oliver and Schäfer. Since their memorable communication in the spring of 1894, the vasomotor properties of the suprarenal glands have been continually studied by the scientific world. Later, beginning with the observations of the remarkable effect of the suprarenal substance on the sympathetic nervous system, Langley

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