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December 5, 1903


JAMA. 1903;XLI(23):1417-1418. doi:10.1001/jama.1903.02490420039013

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At the October meeting of the New York Society for Experimental Biology and Medicine, Dr. S. J. Meltzer, the president, demonstrated some interesting specimens which seem to throw a new light on the circulation in the peripheral nervous system. His paper was on the effect of ligation on the vital staining of nerves. He demonstrated a series of pieces of dried sciatic nerves of rabbits which had received during life intravenous infusions of methylene blue. As is well known, this substance is carried all over the system by the circulation and stains all tissues, even the most delicate parts of the nerve centers, with a distinct blue tinge. By this means the course of the circulation in the nervous system and even certain peculiarities of the anatomic finer structure have been demonstrated. Dr Meltzer found that when single ligatures are applied to the trunks of sciatic nerves in animals intravenously

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