Early in the spring of 1910, and following my presentation of a short paper on tuberculin at one of the meetings of the medical staff of the Otisville Sanatorium, of which I was a member, Dr. E. S. McSweeny, the physician then in charge, asked me to reorganize the tuberculin class among the patients.
After rather an extensive perusal of much of the literature on the subject, I was struck by the divergent views held by the different investigators on tuberculin therapy in general and the matter of dosage and reaction in particular. I then decided to lay aside all my preconceived notions on tuberculin and begin injections with a dose well below any possible reaction, such as 0.000,000,01 gm., and to double each previous dose at weekly intervals, using Koch's B. E. In the last year of this work, patients in the class were started on Koch's Old Tuberculin
SHALET L. CLINICAL REPORT OF FIVE HUNDRED AND SEVENTY-ONE CASES OF PULMONARY TUBERCULOSIS TREATED WITH TUBERCULIN. JAMA. 1914;LXII(15):1160-1164. doi:10.1001/jama.1914.02560400028010