Anaphylactic reactions following the injection of horse-serum in sensitized individuals are of common occurrence, and the various phenomena in animals sensitized to foreign proteins have been extensively studied. Great effort is now being made to unify these manifestations of anaphylaxis and immunity on a single basis, despite their many striking variations.
The introduction into the human circulation of foreign proteins, in the form of bacterial vaccines, is usually in such small amount that there is but slight local and usually no appreciable general reaction.
The following case is of special consequence because of its rarity in the literature, both of anaphylaxis and of vaccine therapy:
Mrs. S. J. P., aged 53, presented a small furuncle on the left forearm and an infected hair follicle in the right axilla. Three years previously she had suffered from boils and was effectively cured with four serial doses of staphylo-streptobacterin. Similar treatment was requested
WALLACE R. AN UNUSUAL CASE OF VACCINE ANAPHYLAXIS. JAMA. 1914;LXII(15):1166-1167. doi:10.1001/jama.1914.02560400034013