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April 25, 1914


JAMA. 1914;LXII(17):1330. doi:10.1001/jama.1914.02560420036017

Now that the cultivation of malarial plasmodia outside of the body has finally been successfully accomplished through the technic devised by Dr. Charles C. Bass and his co-worker Dr. F. M. Johns of the Tulane School of Tropical Medicine, and the splendid results have been verified by Lavinder, Thompson, Ziemann and others,1 it is time to turn attention to some of the lessons which the new experiences are suggesting. Bass2 has lately offered some ideas relative to reproduction of the organisms, suggested by his observations of malarial plasmodia growing in vitro and from experiments made with his cultures. He believes that in the living body the plasmodia can pass from cell to cell only when one cell is in direct contact with another containing a segmenting parasite, and then only when the opening for the exit of merozoites occurs opposite the neighboring cell. The substance of malarial plasmodia

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