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Article
May 9, 1914

HETEROPLASTIC TISSUE GRAFTING EFFECTED THROUGH ROENTGEN-RAY LYMPHOID DESTRUCTION

Author Affiliations

NEW YORK

From the Laboratories of the Rockefeller Institute for Medical Research.

JAMA. 1914;LXII(19):1459. doi:10.1001/jama.1914.02560440015005
Abstract

The relationship between the lymphoid tissue and the mechanism which causes the failure of heteroplastic tissue grafts has been considered in a recent report.1 The chick embryo which lacks this defensive mechanism was shown to be an excellent host for the growth of a variety of tissues derived from foreign species.2 These embryos, however, become as resistant as the adult if supplied with a graft of either adult chicken-spleen or bone-marrow.3 If the deductions from these experiments are correct, it should be possible to effect heterotransplantation in the adult by lessening the activity of the lymphoid tissue. As a matter of fact this has been accomplished up to the present by two distinct methods: (a) by the employment of subcutaneous injections of benzol (benzene, C6H6); (b) by the use of the Roentgen ray. The present preliminary report relates exclusively to the second method. As

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