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This monograph contains a discussion of existing theories, and reports further investigation which supports the author's previous important contributions on the origin of the lymphatic system. The older ideas of the lymphatic capillaries as extensions of simple interstitial spaces is now, and especially through the work of the author and others at Johns Hopkins, completely refuted. They are distinct tubes of endothelium, derived originally by budding from the veins, and they form closed canals as distinct from tissue-spaces as the blood capillaries themselves. In this article special stress is laid on the importance of endothelium as an active growing functional tissue. When it buds off the veins to form lymphatics it has the peculiar property of avoiding the bloodcapillaries, hence forming the independent lymphatic network. These lymphatics invade the body, but apparently never enter the central nervous system, which remains a permanent non-lymphatic area. Lymph-glands are formed by development of
The Origin and Development of the Lymphatic System.. JAMA. 1914;LXII(19):1496. doi:10.1001/jama.1914.02560440052029