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This monograph, which is a separate reprint of one of the Johns Hopkins Hospital reports, consists of a discussion of some of the literature and a report of one case observed by the author, two cases from Johns Hopkins studied by others, and two doubtful cases. One of the most important features of primary carcinoma of the liver, itself a rare tumor, is that in certain cases the neoplasm seems to grow by fresh transformation of liver-cells of adjacent territories into cancercells. If this is a correct interpretation of the processes observed, it signifies that substances or agents of some sort may diffuse from a malignant tumor into surrounding tissues, and there cause previously normal cells to take on the malignant character of growth, a phenomenon of the greatest significance in the problem of the etiology of cancer. Winternitz does not accept this view, but it will seem to some
Primary Carcinoma of the Liver.. JAMA. 1914;LXII(19):1496. doi:10.1001/jama.1914.02560440052030