The activity in bacteriologic investigation which characterized the eighties of the last century led to numerous discoveries and numerous mistakes. Diseases which by analogy ought to have been bacterial were stated to be due to organisms which were afterward shown to be contaminations, and, on the other hand, diseases which at first sight seemed far removed from bacterial action were shown to be intimately associated with micro-organisms. Among the conditions which were investigated at this time were those associated with the formation of salivary calculi, and Galippe, who cultivated bacteria from these concretions, not only assumed a causal relation between the germs and the calculi, but predicted that other forms of calculi would be shown to be of bacterial origin.
So far as the bacterial origin of gallstones is concerned, it was Naunyn who first gave his unreserved support to this view of their origin. The view was not, however,
THE ETIOLOGY OF GALLSTONES.. JAMA. 1906;XLVI(4):278. doi:10.1001/jama.1906.02510310040006