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February 3, 1906


Author Affiliations

Interne New York Postgraduate Hospital.; NEW YORK CITY.

JAMA. 1906;XLVI(5):334-337. doi:10.1001/jama.1906.62510320020001d

This disease of infancy is one about which there has been a great deal of discussion among writers on diseases of the blood since von Jaksch, in 1889, first described the disease which now bears his name. Italian writers recognized and described peculiar forms of grave anemia in children as far back as 1880, which they placed in an intermediate position between leukemia and Hodgkin's disease. Some authorities, Ebstein, Fischl and Cabot, do not recognize it as a clinical entity, but classify all such cases as pernicious anemia, leukemia, or secondary anemia with leucocytosis.

This controversy arises primarily from the fact that in young children there is a tendency for the blood in all forms of severe anemia to retrogress to an embryonal form: added to this, there is a much more active response to chemotactic influences; and a general tendency of the spleen to become hypertrophied in all cachectic

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