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Early in August I received from the druggists Gale & Blocki, a 1 per cent. solution of holocain for testing its anesthetizing virtues. I first tried it on a few normal eyes and on eyes with foreign bodies in the cornea, with the following results: The instillation always caused more or less smarting and burning, which however lasted but about half a minute; it also produced considerable redness of the conjunctiva (palpebral and ocular), which persisted during the whole period of anesthesia. Within one and one-half to two minutes complete anesthesia of the cornea was noted; after six minutes the sensibility of the cornea began to return, but a second instillation prolonged the anesthesia for another five minutes; and if then another drop was instilled the anesthesia could again be continued. It would seem then that the anesthetic effect of holocain can be kept up indefinitely by repeating the instillation
HOTZ FC. HOLOCAIN VS. COCAIN.. JAMA. 1897;XXIX(20):1012. doi:10.1001/jama.1897.02440460032002i