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February 3, 1906


JAMA. 1906;XLVI(5):362. doi:10.1001/jama.1906.02510320048004

When in 1899 v. Dungern found that a specific immunity could be obtained against epithelial cells, and suggested the possibility that in this direction might be sought an immune serum against cancer, intense interest was immediately awakened in the subject of cellular toxic serum. The simplicity of the method of investigation attracted many to the work, for all that was necessary was to inject an emulsion of the cells to be studied into the peritoneal cavity of a laboratory animal, obtain the blood serum of the animal after it had been injected several times, and inject the serum thus obtained into normal animals of the same species as the one that had furnished the original cells. Within a few months the literature teemed with more or less hasty reports of the discovery of serum toxic for nearly every cell in the body. Animals injected with serum of animals immunized against

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