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Fairfield, Iowa, Dec. 5, 1896.
To the Editor:
—In view of the occasional fatal effects of diphtheria antitoxin and the rapidity with which death occurs in these cases, I would suggest the advisability of dividing the administration of the desired dose into several stages at intervals of several minutes between the stages, giving but a fraction of the entire dose at each stage.Tentatively I propose one-fourth, or less, of the intended dose at each stage of the injection, letting an interval of five or preferably ten minutes elapse between the stages of the injection. I do not conceive it would be desirable to withdraw the syringe and re-introduce it when interstages are not longer than ten minutes, but the needle can remain introduced until the injection of the entire dose is effected.In case dying from the antitoxin, fatal collapse has usually resulted within five minutes from the time
Bean JV. Administration of Antitoxin.. JAMA. 1896;XXVII(24):1255. doi:10.1001/jama.1896.02431020037012