The pathology of inebriety is the story of a long series of degenerative changes extending over many years, and also the record of brain storms and explosive liberation of nerve energies acting on defective cells and nerve centers. In all instances these changes appear in the walls of the blood vessels, the nerve cells and dentrites. The inebriate whose brain and body after death exhibit a confused mass of wreckage which the pathologist is often unable to trace back to the exact causes and conditions, has always sclerotic conditions of the large and small arteries, together with atrophic and hyperatrophic states of the heart, kidneys and liver with fatty degeneration, and calcification of the coats of the arteries. These organic changes are so frequently present in inebriates that they constitute a marked pathology which is traceable to the use of alcohol.
A large number of alcoholics die from acute diseases
CROTHERS TD. PATHOLOGY OF INEBRIETY.SUPERINTENDENT WALNUT LODGE HOSPITAL.. JAMA. 1904;XLII(5):294-296. doi:10.1001/jama.1904.92490500014001d