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January 30, 1904


JAMA. 1904;XLII(5):314. doi:10.1001/jama.1904.02490500034006

In a former number1 we noted editorially the reported success of Metschnikoff in infecting the chimpanzee with syphilis. Recently Metschnikoff and Roux2 have given a concise statement of their observations, which are most interesting and which may be of importance in furthering the study of syphilis.

The first chimpanzee, a female, was infected with "syphilitic virus." After twenty-five days a hard sore developed, which Fournier and others were willing to consider of syphilitic nature. A month later about fifteen papules appeared on various parts of the body, and remained until the death of the animal, which occurred fourteen weeks after the inoculation was made. A pneumococcus was cultivated from the heart's blood, and it is supposed this organism gained entrance through a gingivitis and caused death. Before the animal died, however, a second chimpanzee was inoculated on the penis from the now subsiding chancre of chimpanzee number one, and

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