In a former number1 we noted editorially the reported success of Metschnikoff in infecting the chimpanzee with syphilis. Recently Metschnikoff and Roux2 have given a concise statement of their observations, which are most interesting and which may be of importance in furthering the study of syphilis.
The first chimpanzee, a female, was infected with "syphilitic virus." After twenty-five days a hard sore developed, which Fournier and others were willing to consider of syphilitic nature. A month later about fifteen papules appeared on various parts of the body, and remained until the death of the animal, which occurred fourteen weeks after the inoculation was made. A pneumococcus was cultivated from the heart's blood, and it is supposed this organism gained entrance through a gingivitis and caused death. Before the animal died, however, a second chimpanzee was inoculated on the penis from the now subsiding chancre of chimpanzee number one, and
SYPHILIS IN ANTHROPOIDS.. JAMA. 1904;XLII(5):314. doi:10.1001/jama.1904.02490500034006