The plexiform type of neurofibroma is considered by Recklinghausen, Kyrieleis, Kriege, Hurthle, Teichert, Westphalen and others to arise invariably from the connective tissue of nerve trunks. In opposition to this view, Lahmann maintains that such neoplasms may not only originate in the connective tissue of the nerve trunks, but also from that of the blood vessels or of the skin glands or hair follicles as well. His findings have been corroborated in whole or in part by Philippson, Du Mesnil, Verneuil and Löwenstein. Bearing on this mooted question, the following case may present some features of interest:
Family and Personal History.
—R. E., the unfortunate subject of this report (Fig. 1), is aged 19 years. His parents, live brothers and two sisters are living and healthy. There is no hereditary taint. His training in an institute for the blind was thorough, and, all things considered, he is exceptionally bright and
WYNN FB. PLEXIFORM NEUROFIBROMA.. JAMA. 1906;XLVI(7):500–503. doi:10.1001/jama.1906.62510340026002f