In this paper it is proposed to review and summarize previous work on nitrogen and chlorin metabolism, and then to give in detail experiments carried out, at the suggestion and under the direction of Dr. Clowes, on a normal individual and on several cancer patients, and to compare the results of such experiments.
SUMMARY OF THE PREVIOUS WORK.
Much of the previous work loses in value because of the lack of accurate data recording quantities of nitrogenous food and chlorids ingested, quantity of nitrogen and chlorids excreted through the feces, body weight, etc. One very important source of error in the determination of chlorids is the change from solid to liquid food, especially the substitution of a milk diet for the normal solid food. The ratio of chlorids to proteid matter in milk is smaller than in solid food as usually consumed; hence, with milk one expects a reduced chlorid
GLOSSER HH, FRISBIE WS. SOME STUDIES IN METABOLISM OF CANCER PATIENTS AS COMPARED WITH NORMAL INDIVIDUALS.. JAMA. 1906;XLVI(8):561-565. doi:10.1001/jama.1906.62510350011001c