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The patient, an unmarried lady 30 years of age, has suffered from acne rosacea, with pustulation and papulation for about ten years. The entire face was involved with redness, most marked over cheeks and nose, and always worse during menstruation. The patient is well nourished but has suffered from nervousness and despondency, perhaps due largely to her necessary isolation from society on account of the bad appearance of her face. She has been under the professional care of several first-class physicians and all the usual means of treatment have been resorted to, but without avail.
I decided with the consent of my patient to use intradermal injections of formaldehyde in the strength of 1 drop of the 40 per cent. solution to 100 drops of water. These injections are attended with a stinging pain which the patient compares to the sting of a bee. One-half to one minim was injected
McSHANE JT. ACNE ROSACEA TREATED BY INTRADERMAL INJECTIONS OF FORMALDEHYDE.. JAMA. 1897;XXIX(25):1261. doi:10.1001/jama.1897.02440510023001i