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March 10, 1906


JAMA. 1906;XLVI(10):719-722. doi:10.1001/jama.1906.62510370025002

INTERNAL ANTISEPTICS.  The great strides made in the use of antiseptics, after Lister had employed them in surgery with such brilliant results, led to the hope that they might be made available for limiting the development of bacteria in various parts of the human body. From time to time clinicians have reported favorable results from the use of internal antiseptics in such diseases as typhoid fever, but at the present time it is generally acknowledged that complete disinfection of the intestinal tract is impossible and that the treatment of constitutional diseases by means of antiseptics is possible only in a few isolated cases; for example, in malarial fever by quinin, in articular rheumatism by salicylic acid and its compounds, and in syphilis by means of mercurials. Quinin has been shown to have a peculiarly selective and destructive action on the protozoön which causes malarial fever, and perhaps mercury and salicylic

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