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The following report of an extraordinary effect of a much used drug is instructive and of interest as illustrating the idiosyncrasy of individuals in their relation to medicines. In these cases the apparent physiologic action of homatropin hydrobromid was irregular to an extraordinary degree. The two observations here chronicled are the only instances which have come under my notice of excessive persistence of the effect.
I am unable to estimate a percentage of frequency for the occurrence of this accident, but suppose it to be rare, for these two cases are the only instances which have occurred in using homatropin several thousand times. The experience of others in this particular should be of interest to all. It is of moment to every practitioner, for the reason that it is especially in the more urgent cases of persons whose time is of great value that homatropin is employed.
I have just
SHERER JW. UNUSUAL EFFECT OF HOMATROPIN.REPORT OF TWO CASES.. JAMA. 1906;XLVI(20):1526. doi:10.1001/jama.1906.62510470040003