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Article
June 2, 1906

A FURTHER CONTRIBUTION TO THE STUDY OF UNTOWARD SERUM REACTIONS.

JAMA. 1906;XLVI(22):1699-1700. doi:10.1001/jama.1906.02510490045007
Abstract

A few weeks ago1 we referred to the so-called serum disease, in which annoying complications and sequels varying from slight local erythema to troublesome urticaria, joint pains and edema, are encountered with a frequency that has placed obstacles in the way of a wider use of curative serums, and engendered in some a prejudice against them.

Just issued from the Hygienic Laboratory of the Public Health and Marine-Hospital Service2 is a noteworthy publication by Director M. J. Rosenau and Assistant Director John F. Anderson dealing with an elaborate experimental study of a newly identified poisonous action of blood serum. This investigation concerns itself with the guinea-pig and the reaction of this animal to horse serum in particular, both fresh normal horse serum, old serum, dried serum, antitoxic (diphtheric) serum, and the so-called "refined and concentrated" antitoxin obtained by precipitating and dialysing antidiphtheric serum. The authors have amplified and

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