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The intimate relationship between the brain, the spinal cord and the eye, leads us to infer that the pathologic processes implicating the eye should enable us to diagnosticate various morbid processes primarily asserting thenselves in the spinal cord and brain. And while we possess certain data more or less positive in their character, among which pupillary change is prominently figured, we are not always able to define positively by the disturbed pupillary reflex the site of such pathologic processes. It seems, however, that an outline of the pupillary changes consequent upon spinal or brain lesion that are definite in character, should prove advantageous to the general practitioner as well as the ophthalmologist; consequently we will enumerate, as far as practicable, the diseases of the cord and brain with their accompanying pupillary changes which are conspicuously significant and explain their etiology. Since the pupil is nothing more than a circular opening
LYDSTON JA. THE VALUE OF PUPILLARY CHANGE IN SPINAL AND BRAIN DIAGNOSES.. JAMA. 1895;XXV(25):1088-1089. doi:10.1001/jama.1895.02430510024003d