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This consists of a series of lectures delivered at the New York Skin and Cancer Hospital during the spring of 1905. Bulkley believes that by the separation of dermatology as a specialty attention has been directed from the relations existing between the skin and the general economy to the microscopic details and the study of local features. The predisposing and exciting causes of skin lesions are briefly considered, and the urticaria resulting from gastrointestinal derangements. He mentions copaiba, quinin, aconite, belladonna, ergot, opium and turpentine as vegetable drugs which may cause skin eruptions, and iodin and bromin and their compounds, arsenic and certain of the coal-tar preparations such as antipyrin, phenacetin, sulphonal as mineral drugs which may cause skin lesions. Digestive, excretory, respiratory, nervous and cutaneous disturbances are discussed in their relation to skin diseases. Lecture IV, the last, is devoted to a consideration of the diet in these cases
Relations of Diseases of the Skin to Internal Disorders, with Observations on Diet, Hygiene and General Therapeutics.. JAMA. 1906;XLVI(26):2015. doi:10.1001/jama.1906.02510530035026