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July 21, 1906


Author Affiliations


JAMA. 1906;XLVII(3):174-175. doi:10.1001/jama.1906.25210030014002c

Perhaps it would be less presumptuous to entitle this communication "A Poison from the Meningococcus." By this expedient one might at least evade some of the perplexities which now surround the problems relating to the composition, varieties and effects of toxic substances elaborated by pathogenic bacteria. At least it is my desire to escape as far as possible any committal on the head of the exact nature of the agent to be here described, and to record simply the method by which a product with poisonous properties was obtained from cultures of the meningococcus and tested for its toxicologic action.

The subject for these experiments was the horse, and it was by means of intravenous injections that evidences of a powerful poison derived from the meningococcus were first secured. Such toxication was elicited both by the use of living cultures, dead cultures, acidulous cultures in glucose broth; but the most

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