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A female child, aged 3 years, parents of upper class; subject of malnutrition, from whom large amount of pharyngeal adenoids had been removed six weeks before; in addition to diet and general regimen had been given proto-nuclein tablets, 5 grs. each, taken twice to three times a day (Reed & Carnrick's). Had taken these for about a month. Great benefit as regards general health, the condition of the nose, throat and ears had followed. The improvement was mainly ascribed to removal of the adenoid tissue and restoration of nasal breathing. This child was addicted to eating lead pencils, pieces of chalk, etc., and had previously taken medicine of some kind in large quantity without knowledge of the parents.
On February 4 she was observed to be playing with a bottle which had contained proto-nuclein tablets, of which it is supposed twenty-five or thirty remained (125 to 150 grains or 8
WÜRDEMANN HV. CLINICAL NOTE UPON AN OVERDOSE OF PROTO-NUCLEIN.. JAMA. 1896;XXVI(8):376-377. doi:10.1001/jama.1896.02430600028002i