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February 29, 1896


JAMA. 1896;XXVI(9):415-420. doi:10.1001/jama.1896.02430610017002g

Calomel.  —Adopting Schmidt's12 analysis of pancreatic juice, I found that it required 21 grams (323grs.) of the official hydrochloric acid to neutralize 143 grams (2200 grs.) of this artificial pancreatic juice. The proportion was as 1 to 7. One part of hydrochloric acid will neutralize one and one-half parts of potassium hydrate. Then the alkalinity of pancreatic juice is to potassium hydrate as 7 to 1.5, or it requires 4.6 times as much pancreatic juice as caustic potash to neutralize the same weight of muriatic acid. Schmidt's quantities being parts of 1,000, I am thus enabled to place the alkalimety of pancreatic juice at 4.6 parts per 1,000, which agrees remarkably with Matteucci's estimate of the lymph and chyle alkalinity being equivalent to 4.3 parts per 1,000, in terms of potassium hydrate. Bidder and Schmidt estimated the amount of pancreatic fluid daily secreted by man as 7 ounces (224

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