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The Brown-Sequardian theory of the tonic action of testicular extract has probably passed into the category of exploded fads in the opinion of at least the majority of the medical profession. It is a matter therefore of some interest when we see it brought forward again in a couple of scientific papers that make up nearly the whole of the latest issue of Pflueger's Archiv, and supported to a very considerable extent by physiologic experimental proofs. Dr. Oskar Zoth and Dr. Fritz Pregl, of the physiologic institute of Graz, publish the results of ergographic (i.e., dynamographic) investigations on the action of orchic extract in bodily fatigue and capacity, in which they find that, combined with exercise, the daily injections of this substance produce a very decided tonic effect, increasing the capacity for work considerably above that which would follow the exercise alone. This effect, moreover, was enduring and lasted
THE BROWN-SEQUARD METHOD OF TESTICULAR EXTRACT THERAPY.. JAMA. 1896;XXVI(10):488. doi:10.1001/jama.1896.02430620040008