Brügelman of Wiesbaden has had under his care 2,130 cases of asthma and believes that the symptom asthma in all of his cases was due essentially to some disturbance of the central nervous system which is set up by one of three sets of general causes. (1) Traumatic, involving some injury to the brain or medulla. (2) Toxic asthma, due to toxic conditions of the blood as uremia, diabetes mellitus, etc.; under this term he includes cardiac asthma. (3) Reflective, such cases as are due to reflex irritation, particularly involving the air tract. Out of his 2,130 cases he found 7 that were due to cerebral traumatism and 222 that could be referred to toxic conditions. All of the remainder, amounting to 1,900, were due to reflex irritation of some kind. Of this number 665 were referable to the so-called nasal points, and 464 to similar points in the pharynx.
REILLY TF. THE MANAGEMENT OF SOME FORMS OF ASTHMA.. JAMA. 1904;XLII(23):1475-1476. doi:10.1001/jama.1904.92490680015001b