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June 4, 1904


JAMA. 1904;XLII(23):1498. doi:10.1001/jama.1904.02490680038012

Although at the present time we are generally ready to accept without question the idea that the typhoid bacillus is the sole cause of typhoid fever, because of the enormous amount of evidence of various sorts that has accumulated pointing to this view, yet there has always been one weak point in the evidence. The first two of the postulates of Koch that should be fulfilled by an organism before it can be fully accepted as the cause of a given disease have been abundantly satisfied, namely, that the organism must be found constantly present in the disease, and that it must be recovered in pure cultures from the diseased tissues. The third requirement, that the germ produce in an experimental animal the same lesions as are characteristic for the disease in man, has been the stumbling block. Inoculation into animals usually results in the development of acute degenerative changes

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