It is not the purpose of this paper to discuss the numerous theories concerning the etiology and pathology of these interesting conditions, for the multiplicity of ideas is the best evidence of the obscurity which still surrounds them, but to outline a course of treatment which has been beneficial.
Since A. E. Wright, in 1891 and 18931 and in subsequent articles, advocated the use of the chlorid of calcium to hasten the coagulation of the blood, many patients with hemorrhagic tendencies have been greatly helped by it while with others it seems inert. The preparations of the adrenal gland are also of value in many cases.
Boggs,2 in 1904, demonstrated that the lactate of calcium had the same accelerating effect on coagulation as the chlorid.
Wright3 and Paramore,3 in 1905, published the results of a series of experiments in which they used the lactate of calcium
COE JW. THE TREATMENT OF PURPURIC CONDITIONS AND HEMOPHILIA.. JAMA. 1906;XLVII(14):1090-1093. doi:10.1001/jama.1906.25210140026001h