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Article
June 18, 1904

THE RELATION OF SUBINFECTION TO PERNICIOUS ANEMIA.

JAMA. 1904;XLII(25):1629. doi:10.1001/jama.1904.02490700029010
Abstract

While the gross and microscopic pathology of pernicious anemia has been cleared up to a large extent, especially by the work of Warthin, we still seem to be in the dark as regards the etiology of the disease. The view most commonly held is that which assumes the condition to be due to the absorption of bacterial toxins from the intestinal canal, a conception which is opposed by the well-known fact that, at any rate in the usual intestinal bacteria, the colon group, the toxin is not soluble, but is situated in the body of the bacillus itself. In a recent article Charlton1 reports some very interesting work carried on in Adami's laboratory which has a bearing on this subject. The suggestion made by Adami in 1889 that pernicious anemia was probably due to latent infection or subinfection with intestinal bacteria formed the starting point of the research. Rabbits

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