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—On Aug. 23, 1906, I operated on Mrs. C., aged 27, for appendicitis. She had had two previous attacks and refused operation for three days before I operated. Her history, except the previous attacks, has no bearing on the case. She had taken nothing into the stomach but water for 48 hours, and only one-half cup of chocolate for 64 hours. The bowels had been loose before the attack and were in the best of condition at the time of the operation. The administration of chloroform was begun at 9:45 a. m., and lasted one and one-half hours. It was given with great care and was well taken, but required a large quantity, four ounces being used. The operation was what we call clean. The patient rallied well from the anesthetic, vomited only three times, the last time at 5 p. m., and was only slightly nauseated.
CUSHING HE. ACUTE ATROPHY OF THE LIVER FROM CHLOROFORM POISONING.. JAMA. 1906;XLVII(15):1191. doi:10.1001/jama.1906.25210150047002d