The experimental production of glycosuria may be brought about in several ways, the most prominent being by extirpation of the pancreas and the puncture of a certain point in the floor of the fourth ventricle discovered by Claude Bernard. Besides these methods, glycosuria may be brought about by the action of various poisons. Some of these poisons, e. g., phloridzin, while producing glycosuria, do not increase the amount of sugar in the blood, but rather diminish it, and they are supposed to act by injuring the kidney so that its power to hold back the sugar in the blood is destroyed and the blood is drained of sugar. As this process does not conform to the phenomena of diabetes the result of these poisons can not be considered as experimental diabetes, and is of minor interest to the practitioner aside from the use of phloridzin in testing kidney function.
EXPERIMENTAL DIABETES.. JAMA. 1906;XLVII(15):1198. doi:10.1001/jama.1906.02520150054007