GUMMA OF THE HYPOPHYSIS.
In hereditary syphilis, the hypophysis may be enlarged and indurated, due to connective tissue proliferation.1 In acquired syphilis, gumma of the hypophysis has been described by Troisier,2 Weigert,3 Barbacci,4 Birch-Hirschfeld5 and Sokoloff.6 In these cases there can not be much doubt concerning the truth of the diagnosis. In Troisier's case the origin of the gumma is referred to the capsule of the hypophysis. Boyce and Beadles7 detail a case of granulomatous infiltration of the hypophysis which they regard as tuberculous, but without having shown tubercle bacilli to be present. The same uncertainty of diagnosis is attached to Wagner's8 case of "tubercle of the pituitary," which he observed in a girl aged 13 years, without tuberculosis elsewhere.The following case of gumma of the hypophysis consequently merits report on account of the rarity of the lesion:Woman, age
HEKTOEN L. OBSERVATIONS ON GUMMA OF THE HYPOPHYSIS; AND PRIMARY CARCINOMA OF THE URETER.. JAMA. 1896;XXVI(23):1115-1117. doi:10.1001/jama.1896.02430750017001f